Abstract: During the winning phase of building a well-off society in an all-round way and during the “13th Five-Year Plan” period, China further increased its investment in science and technology for disaster prevention and reduction. Guided by the needs of disaster prevention and reduction business and centered on national strategic deployment and business chain and innovation chain, China implemented a number of major scientific and technological projects, and a comprehensive prevention system were formed such as theoretical research on disasters, key technology research and development, equipment development, application demonstration, and professional team building. These laid a solid foundation for the establishment of an innovative system for natural disaster prevention and control in the new period of China during the “Fourteenth Five-Year Plan” period, and promoted the sustained and stable development of the business of disaster prevention and mitigation with Chinese characteristics.