Abstract: The construction in mountain areas in western China has revealed many large-scale bending toppling deformation bodies, and most of them are of soft and hard interlayer structures. In order to further explore the deformation and failure law of anti-dumping soft-hard interbedded rock slope, this study combines the large-scale geotechnical centrifuge test and the joint strength criterion of Hoek-Brown and Mohr-Coulomb, considering the tension-shear and compression-shear failure of the joint surface to carry out test and numerical simulation analysis for this kind of slope. The displacement and stress curve of the monitoring point are combined, the deformation and failure process of the slope is described in detail and the correctness of the proposed strength criterion and the numerical model are verified. Based on this numerical model, the influence of different geometric factors on this kind of slope is examined. The results show that the joint strength criterion of Hoek-Brown and Mohr-Coulomb can accurately simulate the interlaminar dislocation and rock bending of anti-dumping soft-hard interbedded rock slope. The whole process of toppling deformation and failure of this kind of slope is as follows: the interlayer first dislocates, then the slope begins to bend from the foot of the slope, the tension crack appears at the back edge of the slope, and at the same time the slope as a whole bends to the empty surface. Finally, 2 or 3 failure surfaces are formed. With the increase of the dip angle of the rock layer, the first-order failure surface of the slope gradually develops to the depth of the slope. With the decrease of the thickness ratio of the soft/hard strata, the vertical displacement of the top of the slope becomes smaller, and the integrity of slope sliding increases gradually, and with the increase of the thickness ratio of the soft/hard strata, the failure surface of the slope gradually changes from rough 'sawtooth' to smooth 'arc'.