Abstract: Prediction of water inflow of a sub-sea tunnel under the blasting vibration effect is still a difficult subject. This paper takes the sub-sea tunnel between the Wawuzhuang Station and Guizhou Road Station of the Qingdao Metro Line 1 as the engineering background. Based on the equivalent continuum model, the mirror image method is used to deduce the calculation formula for the water inflow of the sub-sea tunnel considering the damage area factor. Through forward modeling and inversion, combined with numerical simulation results and actual engineering monitoring results, the correctness of the formula is comprehensively verified, and the influence mechanism of damage area factors on water inflow is analyzed. The results show that the squeezing effect caused by blasting vibration makes the pore water pressure of surrounding rock around the tunnel rise rapidly in a short time. After reaching the peak value, it began to decline slowly with the weakening and disappearance of blasting vibration. Under the influence of damage zone factors, the water inflow of the tunnel increases gradually with the increasing thickness of the damage zone, but it will not increase continuously with the increase of the coefficient of permeability in the damaged area. Through numerical simulation calculation, the ratio of tunnel water inflow considering blasting damage area is 1.4, and the error is only 4.1% compared with the calculation result of 1.342 deduced in this paper. The calculated results in this study are only 0.53 m³/(d·m) less than the field measured results, and are closer to the measured results than those with the traditional calculation formula, indicating that the calculation formula in this paper is suitable for the calculation of tunnel water inflow considering the factor of damage zone, and are of high engineering application value.