Abstract: Considering the particle morphology of geotechnical materials is essential for accurately assessing slope stability and predicting landslide migration. However, the influence of particle morphology on large-scale slope stability and landslide dynamics remains unclear. To reveal the impact of particle morphology on slope stability and landslide migration characteristics, a two-dimensional slopes of varied particle morphology were constructed using the particle discrete unit method, based on real-world engineering landslide. Two particle morphology parameters, sphericity and angularity, were used to characterize the overall contour characteristics and number of edges of the particles, respectively, and the effects of particle size scaling and particle morphology on the slope stability coefficient were investigated. With the slope damaged by intensity reduction, the migration characteristics of the landslide body were further analyzed. The results show that, in respect of engineering scale landslide, particle size scaling presents a threshold of impact on slope safety factor prediction. Particle sphericity is inversely proportional to slope safety factor, whereas angularity is proportional to slope safety factor, and particle spherical degree is proportional to the average sliding velocity of landslide. The migration area of landslide is affected by the morphology of particles, with a higher sphericity of particles leading to a larger migration area. The difference in energy dissipation characteristics caused by particle morphology is the main internal cause of the change of landslide migration scope and accumulation state. This study can provide basic information for landslide disaster scope prediction and disaster prevention and mitigation engineering.