Abstract: Based on the characteristics of mine geological environment in Guizhou Province, multivariable comprehensive index evaluation method is used to assess the impact of mine geoenvironment. The weights ,valuedetermined standards of variables and the method of cell division are reasonably determined, then the mine geo-environment comprehensive index and evaluation division zones are obtained, which shows that the characteristics of mine geological environment of Guizhou Province. The results can offer some technical basis for the mine geo-environment protection, recovery and controlling.